Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity
- Chee, M. (Melissa)
- Hebert, A.J. (Alex J.)
- Briançon, N. (Nadege)
- Flaherty, S.E. (Stephen E.)
- Pissios, P. (Pavlos)
- Maratos-Flier, E. (Eleftheria)
DOIAbstract
Objective: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state. Since MCHR1 expression is widespread, the neurons supporting the effects of MCH on energy expenditure are not clearly defined. There is a high density of MCHR1 neurons in the striatum, and these neurons are known to be GABAergic. We thus de
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