The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With an objective to discover cisplatin-resistance reversal agents, herein, we report the evaluation of Glycyrrhiza glabra (licorice) extracts and its twelve chemical constituents for inhibition of CYP1B1 (and CYP1A1) enzyme in Sacchrosomes and live human cells. The hydroalcoholic extract showed potent inhibition of CYP1B1 in both Sacchrosomes as well as in live cells with IC50 values of 21 and 16 mg/ mL, respectively. Amongst the total of 12 constituents tested, quercetin and glabrol showed inhibition of CYP1B1 i...
ABSTRACT − P-gp plays a critical role in drug disposition and represents a mechanism for the develop...
Background: Cancer is one of the most life threatening diseases which is in need of newer drug devel...
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse...
© 2017 Elsevier Ltd The development of multi-drug resistance to existing anticancer drugs is one of ...
Glycyrrhiza glabra L., known as licorice, is one of the most famous herbs in the world. In this stud...
Licorice (Glycyrrhiza glabra L.) is one of the most widely used plants worldwide for its various pha...
Drug-induced liver damage is a life-threatening disorder, and one major form of it is the hepatotoxi...
Active substances such as Saponins (41.1 %), volatile oils (2.5 %) and Tannins (13.2 %) are isolated...
Background: We studied the effect of three plant extracts (Glycyrrhiza glabra, Paeonia lactiflora, E...
In an attempt to discover bioactive agents from the herbal medicine Glycyrrhiza glabra (widely known...
Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Ro...
Licorice extracts containing glycyrrhizin exhibit anti-carcinogenic properties. Because glycyrrhizin...
Glycyrrhiza is a genus of about 20 accepted species in the legume family (Fabaceae), with a distribu...
Abstract Cytochrome (CYP) enzymes catalyze the metabolism of numerous exogenous and endogenous subst...
Glycyrrhiza glabra L (Licorice) as native and pasture medicinal plant has most important export rule...
ABSTRACT − P-gp plays a critical role in drug disposition and represents a mechanism for the develop...
Background: Cancer is one of the most life threatening diseases which is in need of newer drug devel...
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse...
© 2017 Elsevier Ltd The development of multi-drug resistance to existing anticancer drugs is one of ...
Glycyrrhiza glabra L., known as licorice, is one of the most famous herbs in the world. In this stud...
Licorice (Glycyrrhiza glabra L.) is one of the most widely used plants worldwide for its various pha...
Drug-induced liver damage is a life-threatening disorder, and one major form of it is the hepatotoxi...
Active substances such as Saponins (41.1 %), volatile oils (2.5 %) and Tannins (13.2 %) are isolated...
Background: We studied the effect of three plant extracts (Glycyrrhiza glabra, Paeonia lactiflora, E...
In an attempt to discover bioactive agents from the herbal medicine Glycyrrhiza glabra (widely known...
Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Ro...
Licorice extracts containing glycyrrhizin exhibit anti-carcinogenic properties. Because glycyrrhizin...
Glycyrrhiza is a genus of about 20 accepted species in the legume family (Fabaceae), with a distribu...
Abstract Cytochrome (CYP) enzymes catalyze the metabolism of numerous exogenous and endogenous subst...
Glycyrrhiza glabra L (Licorice) as native and pasture medicinal plant has most important export rule...
ABSTRACT − P-gp plays a critical role in drug disposition and represents a mechanism for the develop...
Background: Cancer is one of the most life threatening diseases which is in need of newer drug devel...
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse...