Background: Parkin related Parkinson's disease (PD) is differentiated from idiopathic PD by absent or sparse Lewy bodies, and preserved olfaction. The significance of single Parkin mutations in the pathogenesis of PD is debated. Objectives: To assess olfaction results according to Parkin mutation status. To compare the prevalence of Parkin single heterozygous mutations in patients diagnosed with PD to the rate in healthy controls in order to establish whether these single mutations could be a risk factor for developing PD. Methods: Parkin gene mutation testing was performed in young onset PD (diagnosed <50 years old) to identify three groups: Parkin homozygous or compound heterozygote mutation carriers, Parkin single heterozy...
LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy-body pathology at...
Background: Mutations in parkin are estimated to account for as much as 50% of familial Parkinson di...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
Background: Parkin related Parkinson's disease (PD) is differentiated from idiopathic PD by absent...
parkin mutations are the most common identified cause of Parkinson's disease (PD). It has been sugge...
Hyposmia is a common nonmotor symptom in Parkinson's disease (PD) and has been variably detected in ...
OBJECTIVE: To evaluate the relation between olfactory impairment (OI) and other impairment domains i...
Objective: To evaluate the relation between olfactory impairment (OI) and other impairment domains i...
OBJECTIVE: To establish phenotype-genotype correlations in early-onset Parkinson disease (EOPD), we ...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
ObjectiveOlfactory impairment is a potential marker for impending phenoconversion to Parkinson disea...
Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations lea...
A multiethnic series of patients with early-onset Parkinson's disease (EOP) was studied to assess th...
Background: The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onse...
We analysed the parkin gene in a large consecutive series (146) of unrelated early onset Parkinson's...
LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy-body pathology at...
Background: Mutations in parkin are estimated to account for as much as 50% of familial Parkinson di...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
Background: Parkin related Parkinson's disease (PD) is differentiated from idiopathic PD by absent...
parkin mutations are the most common identified cause of Parkinson's disease (PD). It has been sugge...
Hyposmia is a common nonmotor symptom in Parkinson's disease (PD) and has been variably detected in ...
OBJECTIVE: To evaluate the relation between olfactory impairment (OI) and other impairment domains i...
Objective: To evaluate the relation between olfactory impairment (OI) and other impairment domains i...
OBJECTIVE: To establish phenotype-genotype correlations in early-onset Parkinson disease (EOPD), we ...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
ObjectiveOlfactory impairment is a potential marker for impending phenoconversion to Parkinson disea...
Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations lea...
A multiethnic series of patients with early-onset Parkinson's disease (EOP) was studied to assess th...
Background: The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onse...
We analysed the parkin gene in a large consecutive series (146) of unrelated early onset Parkinson's...
LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy-body pathology at...
Background: Mutations in parkin are estimated to account for as much as 50% of familial Parkinson di...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...