Electrographic indices in migraine patients: A systematic review and meta-analysis

Background and aim Migraine patients can exhibit autonomic dysregulation, in turn leading to cardiac conduction and repolarization abnormalities. This systematic review and meta-analysis evaluated the electrocardiographic changes in migraineurs. Method PubMed and Embase databases were searched for human studies using the search terms ‘migraine’ and ‘electrocardiogram’ until 15th December 2018, identifying 108 and 131 studies. Results Thirteen studies involving 667 migraineurs and 208 normal subjects included (mean age=30.7, total male percentage=19.8%) were included. A longer mean QTc interval (standard mean difference=7.89, 95% confidence interval=[3.29, 12.49], p=0.0008) and higher frequency of QTc prolongation (risk ratio [RR]=6.23, [2.86–13.58], p