Retrospective study comparing two embryo transfer versus three embryo transfer after IVF and ICSI in Hospital Sultanah Nur Zahirah

Objective: A study was performed in Hospital Sultanah Nur Zahirah, Kuala Terengganu to determine the prevalence of clinical pregnancies, and the pregnancy outcomes in patients undergoing IVF after two or three embryo transfer. Method: All infertility patients subjected to IVF/ICSI from January 2010 – March 2015 in Reproductive Unit were retrospectively reviewed using infertility record and clinical data base via HIS computerized system. The details were entered into data collection form for analysis. Result A total of 212 patients were recruited in this study, with 106 patients in each group. There was a significant association between the pregnancy rate and the number of embryos transferred. Pregnancy rate after two embryo transferred group was 30(28.3%), while the pregnancy rate after three embryo transferred group was 49(46.2%).The incidence of multiple pregnancy increased significantly when higher number of embryos had been transferred. The incidence of twin pregnancy was 2(1.9%) when two embryos were transferred and 9 (8.5%) when three embryos were transferred. (p-value=0,018) A triplet pregnancy was recorded in the three embryo transferred group while there was none in two embryo transferred group. The incidence of miscarriage and ectopic pregnancy showed no difference statistically between the two groups. Conclusion: The clinical pregnancy rate increased with increased in the number of embryo transferred, however there also increased in the incidence of multiple pregnancy. Meanwhile, the incidence of miscarriage and ectopic pregnancy were not affected by the number of embryos transfer