Effectiveness Test of Akar Kucing Plant Extract (Acalypha indica Linn.) To Lower Total Cholesterol Levels in Rats (Rattus novergicus) Which Were Induced with a Hypercholesterolemic Diet

This research aims to determine the effect ofethanol extract of Acalypha indica Linn on the total cholesterol levels of rats that were induced with pork oil. This was an experimental research study. The 20 rats were divided into five groups. Each group consisted of four rats. The groups were 1) positive control, 2) negative control, 3) extract dose of 200 mg/kgBW, 4) extract dose of 400 mg/kgBW and 5) extract dose of 800 mg/kgBW. Groups two to five were given pork oil as a hypercholesterolemia diet for 28 days and then given the appropriate treatment based on the group. The results showed that 1) the average total cholesterol level increased after the administration of pork oil from 160 mg/dL to 232 mg/dL, 2) dose of 200 mg/kgBW, 400 mg/kgBW and 800 mg/kgBW showed a decline in the total cholesterol level by 189 mg/dl, 128 mg/dl, and 177 mg/dl. The research concluded that Acalypha indica Linn. extract at a dose of 200 mg/kgBW, 400 mg/kgBW and 800 mg kgBW has an effect in relation to lowering the cholesterol level of rats which had been induced with pork oil Keywords—Acalypha indica Linn.; total cholesterol; hypercholesterolemi