Pengaruh Pemberian Ekstrak Bunga Rosella (Hibiscus Sabdariffa Linn.) Terhadap Gambaran Histopatologi Hepar Mencit (Mus Musculus) Jantan yang Dipapar Pb Asetat

The research aims was to study the histological change of mice's (Mus musculus) liver that were given the extract of rosella (Hibiscus sabdariffa L.) and were exposed to Plumbum acetate per oral. It was used 25 male mice (Mus musculus) as the sample that were divided into five groups by simple random sampling. Group Control negative of the control was given CMC - Na and aquadest, Group Control positive were given 20 mg Plumbum acetate, Group PI, P2 and P3 were given 200 mg, 400 mg, 800 mg of rosella (Hibiscus sabdariffa L.) extract and 20 mg Plumbum acetate. The treatment was given during 21 days by giving Plumbum acetate oncein a hour after giving the extract. On the 29th day, all of the mice (Mus musculus) were necropsied then the liver was taken and processed by Hematoxylin eosin staining method. The examination of histological change was conducted based on the necrosies, degeneration, activated ku ..ppfer cell and sinusoidal dilatation. The result of statistical analysis using Kruskal Wallis and Mann - Whitney Test. It was concluded that the rosella (Hibiscus sabdariffa L.) extract with dose could influence on the liver damage which was exposed with Plumbum acetate per oral Keywords: rosella (Hibiscus sabdariffa Linn.), mice (Mus musculus), plumbum acetate(Pb asetat), histopatologi, live