Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti

The literature devoted to changes in the expression of the renin-angiotensin system (RAS) proteins of cancer cells was analyzed. The dynamics of RAS protein expression in malignant tumors and the possible role of epigenetic mechanisms in these processes are briefly reviewed. Through research of the epigenetic mechanisms in cancer, principally new techniques for their correction based on the use of selective regulatory systems of covalent modification of histone proteins (for example, deacetylase inhibitor) and microRNA synthesis technologies have been developed. Literature data show promising pharmacological correction of epigenetic modification of chromatin in the treatment of cancer.Analizirana je literatura posvećena promjenama u izraženosti RAS proteina stanica raka. Daje se kratak pregled dinamike izraženosti RAS proteina kod zloćudnih tumora i moguće uloge epigenetskih mehanizama u ovim procesima. Istraživanje epigenetskih mehanizama kod raka rezultiralo je razvojem bitno novih tehnika za njihovo ispravljanje, utemeljenih na primjeni selektivnih regulatornih sustava kovalentne modifikacije histona (npr. inhibitor deacetilaze) i tehnologije sinteze mikroRNA. Literaturni podaci pokazuju obećavajuće farmakološko ispravljanje epigenetske modifikacije kromatina u liječenju raka