International audienceThe development of complex software-intensive systems involves many stakeholders who contribute their expertise on specific aspects of the system under construction. Domain-specific languages (DSLs) are typically used by stakeholders to express their knowledge of the system using dedicated tools and abstractions. In this chapter, we explore different scenarios that lead to the globalization of DSLs through two motivating case studies – a command and control wind tunnel and a smart emergency response system – and outline the concrete engineering challenges they raise. Finally, we list some of the general research challenges related to the globalization of DSMLs and discuss some promising approaches for addressing them