Regioselective Pd-Catalyzed Carbopalladation/Decarboxylative Allylic Alkynylation of ortho -Iodoallenamides with Alkynyl Carboxylic Acids

International audienceA regioselective Pd-catalyzed domino carbopalladation/decarboxylative allylic alkynylation of ortho-iodoallenamides with alkynyl carboxylic acids was studied. This domino process, based on the consecutive formation of C(sp2)–C(sp2) and C(sp3)–C(sp) bonds, was originally achieved for the design of a novel library of prop-2-ynyl isoquinolinones and then extended to indoles. Finally, a general three-step one-pot strategy involving in situ generation of allenamide, π-allyl-Pd complex formation, and decarboxylative allylic alkynylation was subsequently set up