An increasing percentage of the world’s population lives in cities and therefore here the challenges of sustainable development are most concentrated. For this reason, the organizational structure of the city is today constantly questioned. The multidimensional perspective of sustainable development implies a systemic and integrated approach that requires new assessment tools able to identify the multidimensional impacts of the transformation/regeneration of cities. This paper aims to contribute to the international debate about the role of cities in achieving sustainable development and to make operational, in the evaluation field, the concepts driving the transformations of cities and territories. The case study of Pozzuoli (Italy) repres...