Clinical and electrocardiographic predictors of positive response to the intravenous sodium channel blockers in patients suspected of the Brugada syndrome

Background/objectives: Sodium channel blockers are used to unmask the diagnostic ECG pattern of the Brugada syndrome (BrS) in case of a non-diagnostic baseline ECG. The aim of the study was to determine clinical and ECG predictors of a positive challenge test in patients suspected to the BrS. Methods: A total of 106 consecutive patients (91 men; mean age, 35 ± 12 years) suspected of the BrS underwent the intravenous sodium channel blocker challenge test with procainamide or flecainide. Results: Of the 106 patients, positive tests were detected in 20 (19) patients. During test, a transient episode of a second-degree atrioventricular block and isolated ventricular ectopies were observed in 1 (0.9) and 2 (1.9) patients, respectively. A QRS prolongation � 30 was observed in 4 (3.8) patients. Baseline QRS duration in V1 � 110 ms had a sensitivity of 70 and a specificity of 80 for a positive response. An ST-segment elevation � 0.17 mV in V2 had a sensitivity of 60 and a specificity of 82 for a positive response. Of the multiple clinical and ECG variables entered into a binary logistic regression analysis, a history of syncope (P = 0.001), previous cardiac arrest (P = 0.001), baseline QRS duration in V1 � 110 ms (P = 0.001), and baseline ST-segment elevation in V2 � 0.17 mV (P = 0.012) emerged as the independent predictors of a positive response to the intravenous challenge with sodium channel blockers. Conclusion: The results of the sodium channel blocker challenge test can be predicted by clinical presentation and baseline ECG features. © 2012 Elsevier Ireland Ltd