Synthesis, characterization and cytotoxic activity of 8-hydroxyquinoline derivatives

The cytotoxic effects of synthesized quinoline derivatives were tested against the leukemia derived Nalm6 cell lines. The preliminary cytotoxicity screening program revealed that the investigated compounds induced 50 inhibition of the cell at micromolar concentrations and thus could be considered as biologically active. The compound of 5-chloro-8-hydroxyquinolinium chloride proved superior to the remaining agents. The synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopy. Moreover, the crystal structure of 5-chloro-8-hydroxyquinolinium chloride was solved which confirms the several hydrogen bonding in the solid state of this compound that stabilized crystal packing. © 2010 RJPBCS