Add to ORKGThis study compared the possible protective effects of silymarin and melatonin against gentamicin (GEN)-induced nephrotoxicity in rats. Rats were allocated to 6 groups: Group I, control group; Groups II and III, administered with silymarin or melatonin; Group IV, injected with GEN; and Groups V and VI, administered with silymarin or melatonin, and then injected with GEN. Compared with the rats in the control group, all rats injected with GEN significantly presented elevated levels of serum creatinine and urea that was accompanied by an increase in relative kidney weight, increase in renal reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and reduction in renal glutathione (GSH) level and superoxide dismutase (SOD) activity. Si...
Background: Tramadol (TD) has played an important role in the treatment of pain. However, renal toxi...
Background: Drug induced nephrotoxicity, one of the most common renal problem, is a challenge to dea...
Aim: The aim of the study was to investigate the effect of melatonin on the renal injury resulting f...
The risk of serious side-effects as nephrotoxicity is the principal limitation of gentamicin (GEN) t...
Acute renal failure is a major complication of gentamicin (GEN), which is widely used in the treatme...
Objective: The global prevalence of Chronic Kidney Disease (CKD) was 9.1% (697.5 million cases). Chr...
Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Hype...
Copyright © 2012 Pavle Randjelovic et al. This is an open access article distributed under the Creat...
Gentamicin (GM) is an aminoglycoside antibiotic that possesses a wide range of anti-microbial activi...
Background: Nephrotoxicity is a known deleterious effect of Aminoglycoside antibiotics. This class o...
Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug...
Introduction: Paraquat is a quaternary nitrogen herbicide which induces kidney toxicity due to produ...
Introduction: Diclofenac (DIC), a phenylacetic acid compound which belongs to nonsteroidal anti-infl...
Arabic gum (AG) is a complex polysaccharide used as suspending agent. It has been widely used by eas...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Background: Tramadol (TD) has played an important role in the treatment of pain. However, renal toxi...
Background: Drug induced nephrotoxicity, one of the most common renal problem, is a challenge to dea...
Aim: The aim of the study was to investigate the effect of melatonin on the renal injury resulting f...
The risk of serious side-effects as nephrotoxicity is the principal limitation of gentamicin (GEN) t...
Acute renal failure is a major complication of gentamicin (GEN), which is widely used in the treatme...
Objective: The global prevalence of Chronic Kidney Disease (CKD) was 9.1% (697.5 million cases). Chr...
Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Hype...
Copyright © 2012 Pavle Randjelovic et al. This is an open access article distributed under the Creat...
Gentamicin (GM) is an aminoglycoside antibiotic that possesses a wide range of anti-microbial activi...
Background: Nephrotoxicity is a known deleterious effect of Aminoglycoside antibiotics. This class o...
Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug...
Introduction: Paraquat is a quaternary nitrogen herbicide which induces kidney toxicity due to produ...
Introduction: Diclofenac (DIC), a phenylacetic acid compound which belongs to nonsteroidal anti-infl...
Arabic gum (AG) is a complex polysaccharide used as suspending agent. It has been widely used by eas...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Background: Tramadol (TD) has played an important role in the treatment of pain. However, renal toxi...
Background: Drug induced nephrotoxicity, one of the most common renal problem, is a challenge to dea...
Aim: The aim of the study was to investigate the effect of melatonin on the renal injury resulting f...