Stereoselective synthesis of P-Stereogenic N-Phosphinyl compounds

A number of P-stereogenic N-phosphinyl compounds were stereoselectively prepared in good yields by a straightforward approach, thanks to the diversified and, up until now, unexplored reactivity of (R)- and (S)-dicyclohexylidene-D-glucose methyl phenyl phosphinates toward metal amides. Under adequate conditions, structurally different phosphinamides with one or two P-chiral centers were obtained.We are grateful to the Spanish Ministerio de Economía y Competitividad (MEC) (grant number CTQ2013‐49066‐C2‐2‐R) and the Junta de Andalucía (grant number P11‐FQM‐08046) for financial support