RATIONALE: The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphisms, most are located within regulatory intergenic or intronic sequences, with variation in VCS function. Two highly correlated polymorphisms (r2>0.99) associated with VCS functional variation (rs13165478 and rs13185595) occur 5' to the gene encoding the basic helix-loop-helix transcription factor HAND1 (heart- and neural crest derivatives-expressed protein 1). OBJECTIVE: Here, we test the hypothesis that these polymorphisms influence HAND1 transcription thereby influencing VCS development and f...
Summary: Gata4, Hand2, Mef2c, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pace...
Aims: To test if a human Hand1 frame shift mutation identified in human samples is causative of h...
AbstractThe basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac devel...
RATIONALE: The ventricular conduction system (VCS) rapidly propagates electrical impulses through th...
Rationale The ventricular conduction system (VCS) rapidly propagates electrical impulses through th...
Aims: To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryon...
Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant c...
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essentia...
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essentia...
Hand1 is a basic Helix-loop-Helix transcription factor that exhibits post-translationally regulated ...
Contains fulltext : 108002.pdf (publisher's version ) (Open Access)The contraction...
HAND1 is a basic helix-loop-helix (bHLH) transcription factor essential for mammalian heart developm...
Hypoplasia of the human heart is the most severe form of congenital heart disease (CHD) and usually ...
Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence i...
The contraction pattern of the heart relies on the activation and conduction of the electrical impul...
Summary: Gata4, Hand2, Mef2c, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pace...
Aims: To test if a human Hand1 frame shift mutation identified in human samples is causative of h...
AbstractThe basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac devel...
RATIONALE: The ventricular conduction system (VCS) rapidly propagates electrical impulses through th...
Rationale The ventricular conduction system (VCS) rapidly propagates electrical impulses through th...
Aims: To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryon...
Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant c...
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essentia...
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essentia...
Hand1 is a basic Helix-loop-Helix transcription factor that exhibits post-translationally regulated ...
Contains fulltext : 108002.pdf (publisher's version ) (Open Access)The contraction...
HAND1 is a basic helix-loop-helix (bHLH) transcription factor essential for mammalian heart developm...
Hypoplasia of the human heart is the most severe form of congenital heart disease (CHD) and usually ...
Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence i...
The contraction pattern of the heart relies on the activation and conduction of the electrical impul...
Summary: Gata4, Hand2, Mef2c, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pace...
Aims: To test if a human Hand1 frame shift mutation identified in human samples is causative of h...
AbstractThe basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac devel...