Add to ORKGRecent work in biomolecule-metalorganic framework (MOF) composites has proven to be an effective strategy for the protection of proteins. However, for other biomacromolecules such as nucleic acids, the encapsulation into nano MOFs and the related characterizations are in their infancy. Herein, encapsulation of a complete gene-set in zeolitic imidazolate framework-8 (ZIF-8) MOFs and cellular expression of the gene delivered by the nano MOF composites are reported. Using a green fluorescent protein (GFP) plasmid (plGFP) as a proof-of-concept genetic macromolecule, successful transfection of mammalian cancer cells with plGFP for up to 4 days is shown. Cell transfection assays and soft X-ray cryo-tomography (cryo-SXT) demonstrate the feasibilit...
The delivery of a full plasmid, encoding the green fluorescent protein gene into African monkey kidn...
The formation of biofunctionalized metal–organic frameworks (MOFs) by growing them on a variety of m...
The protective capacity and applications of biomimetically mineralized biomacromolecule zeolitic imi...
Recent work in biomolecule-metal-organic framework (MOF) composites has proven to be an effective st...
Recent work in biomolecule-metal–organic framework (MOF) composites have proven to be an effective s...
The intracellular delivery and functionalization of genetic molecules play critical roles in gene‐ba...
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged as n...
Many living organisms are capable of producing inorganic materials of precisely controlled structure...
Many living organisms are capable of producing inorganic materials of precisely controlled structure...
Zeolitic imidazolate framework-8 (ZIF-8) and its composites have diverse applications. However, ZIF-...
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged asno...
Vaccines have an innate tendency to lose their structural conformation upon environmental and chemic...
Metal–organic frameworks (MOFs) are an emerging class of nanocarriers for drug delivery, owing to th...
Metal–organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or cl...
MOFs have demonstrated outstanding properties for the protection and controlled release of different...
The delivery of a full plasmid, encoding the green fluorescent protein gene into African monkey kidn...
The formation of biofunctionalized metal–organic frameworks (MOFs) by growing them on a variety of m...
The protective capacity and applications of biomimetically mineralized biomacromolecule zeolitic imi...
Recent work in biomolecule-metal-organic framework (MOF) composites has proven to be an effective st...
Recent work in biomolecule-metal–organic framework (MOF) composites have proven to be an effective s...
The intracellular delivery and functionalization of genetic molecules play critical roles in gene‐ba...
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged as n...
Many living organisms are capable of producing inorganic materials of precisely controlled structure...
Many living organisms are capable of producing inorganic materials of precisely controlled structure...
Zeolitic imidazolate framework-8 (ZIF-8) and its composites have diverse applications. However, ZIF-...
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged asno...
Vaccines have an innate tendency to lose their structural conformation upon environmental and chemic...
Metal–organic frameworks (MOFs) are an emerging class of nanocarriers for drug delivery, owing to th...
Metal–organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or cl...
MOFs have demonstrated outstanding properties for the protection and controlled release of different...
The delivery of a full plasmid, encoding the green fluorescent protein gene into African monkey kidn...
The formation of biofunctionalized metal–organic frameworks (MOFs) by growing them on a variety of m...
The protective capacity and applications of biomimetically mineralized biomacromolecule zeolitic imi...