Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer. Angiogenesis is controlled by delicate balance between pro- and anti-angiogenic signals. While pro-angiogenic signaling has been extensively investigated, how developmentally regulated, naturally occurring anti-angiogenic molecules prevent the excessive growth of vascular and lymphatic vessels is still poorly understood. In this review, we summarize the current knowledge on how semaphorins and their receptors, plexins and neuropilins, control normal and pathological angiogenesis, with an emphasis on semaphorin-regula...
The axon guidance cues semaphorins (Semas) and their receptors plexins have been shown to regulate b...
Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or ...
Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified as axo...
Recent studies revealed that a class III semaphorin, semaphorin 3E (Sema3E), acts through a single-p...
SummaryThe vertebrate circulatory system is composed of closely related blood and lymphatic vessels....
Semaphorins, a large family of membrane-bound and secreted proteins, signal through their transmembr...
Secreted class 3 semaphorins (Sema3), which signal through plexin receptors and mostly use neuropili...
Secreted class 3 semaphorins (Sema3), which signal through plexin receptors and mostly use neuropili...
Semaphorins are mainly known as guidance signals in development, acting through receptors called Ple...
Semaphorins are mainly known as guidance signals in development, acting through receptors called Ple...
Semaphorins are a large family of secreted and membrane-bound molecules initially implicated in the ...
During organogenesis, patterning is primarily achieved by the combined actions of morphogens. Among ...
The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of ner...
BACKGROUND: The semaphorins and their receptors, the plexins, are proteins related to c-Met and the ...
Class-3 semaphorins are anti-angiogenic and anti-tumorigenic guidance factors that bind to neuropili...
The axon guidance cues semaphorins (Semas) and their receptors plexins have been shown to regulate b...
Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or ...
Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified as axo...
Recent studies revealed that a class III semaphorin, semaphorin 3E (Sema3E), acts through a single-p...
SummaryThe vertebrate circulatory system is composed of closely related blood and lymphatic vessels....
Semaphorins, a large family of membrane-bound and secreted proteins, signal through their transmembr...
Secreted class 3 semaphorins (Sema3), which signal through plexin receptors and mostly use neuropili...
Secreted class 3 semaphorins (Sema3), which signal through plexin receptors and mostly use neuropili...
Semaphorins are mainly known as guidance signals in development, acting through receptors called Ple...
Semaphorins are mainly known as guidance signals in development, acting through receptors called Ple...
Semaphorins are a large family of secreted and membrane-bound molecules initially implicated in the ...
During organogenesis, patterning is primarily achieved by the combined actions of morphogens. Among ...
The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of ner...
BACKGROUND: The semaphorins and their receptors, the plexins, are proteins related to c-Met and the ...
Class-3 semaphorins are anti-angiogenic and anti-tumorigenic guidance factors that bind to neuropili...
The axon guidance cues semaphorins (Semas) and their receptors plexins have been shown to regulate b...
Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or ...
Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified as axo...