Natural Climbers: Insights from Avian Physiology at High Altitude

This is the author accepted manuscript. The final version is available from Mary Ann Liebert via the DOI in this recordHigh altitudes are physiologically challenging: the hypobaria, hypoxia, cold, andincreased UV radiation means humans ascending to high-altitude faster than they acclimatise risk life-threatening illnesses. Despite such challenges, birds can thrive at high altitudes and some even complete metabolically costly migrations across the world’s highest mountain ranges. We outline the aspects of avian anatomy and physiology that confer advantages at each level of the oxygen transport cascade and compare them with those of human and non-human mammals. We also discuss additional adaptations that have been described for high-altitude specialist species of birds and how these are mirrored in high-altitude adapted mammals