Energy coupling in ABC exporters.
- Van Veen, Hendrik W.
- Singh, Himansha
- Agboh, Kelvin
- Fagg, Lisa A
- Guo, Dawei
- Swain, Brendan
- de Kruijf, Robbin F
- Guffick, Charlotte
Publication date
November 2019
DOI Publisher
Organisation for Economic Co-Operation and Development (OECD)Abstract
Multidrug transporters are important and interesting molecular machines that extrude a wide variety of cytotoxic drugs from target cells. This review summarizes novel insights in the energetics and mechanisms of bacterial ATP-binding cassette multidrug transporters as well as recent advances connecting multidrug transport to ion and lipid translocation processes in other membrane proteins
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