Long-term outcomes of trials in the National Institute for Health and Care Excellence depression guideline

The forthcoming National Institute for Health and CareExcellence depression guideline reviews short-term outcomesfor long-term depression. We present effect sizes for long-termoutcomes in trials that report these data. Psychological therapiesbecome more effective, whereas antidepressants becomeless effective over the long term. We review other forms oflongitudinal research that support these findings