Industry 4.0 is a name used to indicate a ‘fourth industrial revolution’, characterised by the emergence of smart factories in which cyber-physical systems monitor physical processes and communicate with each other and human beings in real time. European Member States and regions are committed to adapt their innovation systems to the trends of Industry 4.0 and Europe as a whole is facing the challenge of finding a balance between promoting research and innovation excellence and putting less advanced regions in the position to benefit from the ongoing industrial revolution. However, relatively little is known about the magnitude of this economic phenomenon, the comparative advantages of countries and regions and their technological specialis...