The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally regulated by SRSF1, we performed a high-throughput deep sequencing analysis of polysomal fractions in cells overexpressing SRSF1. We identified approximately 1,500 mRNAs that are translational targets of SRSF1. These include mRNAs encoding proteins involved in cell cycle regulation, such as spindle, kinetochore and M phase proteins, which are essential for accurate chromosome segregation. Indeed, we show that translational activity of SRSF1 is required for normal mitotic progression. Furthermore, we found that mRNAs that disp...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
regulates homologous recombination-mediated DNA repair Xiaolong He1,2 * and Pei Zhang1 Background: O...
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. SR prote...
The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing re...
The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing re...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
No potential conflicts of interests were disclosed. Serine/Arginine Splicing Factor 1 (SRSF1) is the...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Over the past decade, alternative splicing has been progressively recognized as a major mechanism re...
Background: SFRS1 is a member of the splicing factor protein family. Through a specific sequence of ...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transfo...
One of the best-studied splicing regulator is SRSF1 (formerly known as SF2/ASF, Manley et al., 2010)...
The serine/arginine-rich (SR-) family proteins constitute a diverse group of pre-mRNA splicing fact...
International audienceThe transcription factor E2F1 belongs to the E2F family and plays a crucial ro...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
regulates homologous recombination-mediated DNA repair Xiaolong He1,2 * and Pei Zhang1 Background: O...
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. SR prote...
The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing re...
The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing re...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
No potential conflicts of interests were disclosed. Serine/Arginine Splicing Factor 1 (SRSF1) is the...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Over the past decade, alternative splicing has been progressively recognized as a major mechanism re...
Background: SFRS1 is a member of the splicing factor protein family. Through a specific sequence of ...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transfo...
One of the best-studied splicing regulator is SRSF1 (formerly known as SF2/ASF, Manley et al., 2010)...
The serine/arginine-rich (SR-) family proteins constitute a diverse group of pre-mRNA splicing fact...
International audienceThe transcription factor E2F1 belongs to the E2F family and plays a crucial ro...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
regulates homologous recombination-mediated DNA repair Xiaolong He1,2 * and Pei Zhang1 Background: O...
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. SR prote...