An approach is described for simulating data sequence, genotype, and phenotype data to study genomic selection and genome-wide association studies (GWAS). The simulation method, implemented in a software package called AlphaDrop, can be used to simulate genomic data and phenotypes with flexibility in terms of the historical population structure, recent pedigree structure, distribution of quantitative trait loci effects, and with sequence and single nucleotide polymorphism-phased alleles and genotypes. Ten replicates of a representative scenario used to study genomic selection in livestock were generated and have been made publicly available. The simulated data sets were structured to encompass a spectrum of additive quantitative trait loci ...
A panel of FORTRAN 90 functions was developed to simulate the distribution of bi-allelic (e.g., SNP)...
Simulation is an invaluable tool for investigating the effects of various population genetics modeli...
Motivation: Simulation is a critical part of method development and assessment. With the increasing ...
An approach is described for simulating data sequence, genotype, and phenotype data to study genomic...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Phenotypic variation can partly be explained by genetic variation, such as variation in single nucle...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Abstract Background There is a great interest in understanding the genetic architecture of complex t...
Simulation studies in population genetics play an important role in helping to better understand the...
Abstract Background To evaluate statistical methods for genome-wide genetic analyses, one needs to b...
We present ms2gs, a combined coalescence – gene dropping (i.e. backward–forward) simulator for compl...
Summary: GWAsimulator implements a rapid moving-window algorithm to simulate genotype data for case-...
A panel of FORTRAN 90 functions was developed to simulate the distribution of bi-allelic (e.g., SNP)...
Simulation is an invaluable tool for investigating the effects of various population genetics modeli...
Motivation: Simulation is a critical part of method development and assessment. With the increasing ...
An approach is described for simulating data sequence, genotype, and phenotype data to study genomic...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Phenotypic variation can partly be explained by genetic variation, such as variation in single nucle...
Ten replicates of a livestock data structure were simulated. The structure was designed to cover a s...
Abstract Background There is a great interest in understanding the genetic architecture of complex t...
Simulation studies in population genetics play an important role in helping to better understand the...
Abstract Background To evaluate statistical methods for genome-wide genetic analyses, one needs to b...
We present ms2gs, a combined coalescence – gene dropping (i.e. backward–forward) simulator for compl...
Summary: GWAsimulator implements a rapid moving-window algorithm to simulate genotype data for case-...
A panel of FORTRAN 90 functions was developed to simulate the distribution of bi-allelic (e.g., SNP)...
Simulation is an invaluable tool for investigating the effects of various population genetics modeli...
Motivation: Simulation is a critical part of method development and assessment. With the increasing ...