Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project
- Bassetti, M.
- Giacobbe, D.R.
- Vena, A.
- Trucchi, C.
- Ansaldi, F.
- Antonelli, M.
- Adamkova, V.
- Alicino, C.
- Almyroudi, M.P.
- Atchade, E.
- Azzini, A.M.
- Carannante, N.
- Carnelutti, A.
- Corcione, S.
- Cortegiani, A.
- Dimopoulos, G.
- Dubler, S.
- Garcia-Garmendia, J.L.
- Girardis, M.
- Cornely, O.A.
- Ianniruberto, S.
- Kullberg, B.J.
- Lagrou, K.
- Bihan, C. Le
- Luzzati, R.
- Malbrain, M.
- Merelli, M.
- Marques, A.J.
- Martin-Loeches, I.
- Mesini, A.
- Paiva, J.A.
- Peghin, M.
- Raineri, S.M.
- Rautemaa-Richardson, R.
- Schouten, J.A.
- Brugnaro, P.
- Spapen, H.
- Tasioudis, P.
- Timsit, J.F.
- Tisa, V.
- Tumbarello, M.
- Berg, C. van den
- Veber, B.
- Venditti, M.
- Voiriot, G.
- Wauters, J.
- Montravers, P.
DOIAbstract
BACKGROUND: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). RESULTS: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odd...