Local modulation of pulmonary vascular function

THESIS 5621The aim of the present study was to investigate the role of endothelial smooth muscle interaction in the local modulation of pulmonary vascular function. The main part of the work was carried out in isolated rings of porcine pulmonary artery suspended for isometric tension in an organ chamber preparation. In order to further investigate vascular responses, additional immunohistochemical, biochemical (enzyme assays, western blots) and molecular (Northern blots) methods were employed