Add to ORKGThe cytochromes P450s (CYPs) are hemoproteins involved in the cellular detoxification function. The CYPs active site is buried inside the protein, but it can be accessed by the ligands through channels. With a recent method based upon the Delaunay triangulation of the protein, and implemented in the CCCPP software, we modelized geometrically these channels for several human isoforms, including the 3A4, located in the human liver and responsible of the metabolization of an important number of drugs, in order to build a sterical filter devoted to high throughput virtual screening of chemical libraries. This approach let us to get information on mechanisms of opening and closing of the channels, allowing to explain how large ligands can access...
Although the majority of enzymes have buried active sites, very little is known about the energetics...
Although the majority of enzymes have buried active sites, very little is known about the energetics...
Cytochromes P450 (CYP450s), in particular, CYP19A1 and CYP17A1, are key clinical targets of breast a...
The cytochromes P450s (CYPs) are hemoproteins involved in the cellular detoxification function. The ...
Les cytochromes P450s (CYPs) sont des hémoprotéines intervenant dans la fonction de détoxication cel...
Les cytochromes P450s (CYPs) sont des hémoprotéines intervenant dans la fonction de détoxication cel...
Les cytochromes P450s (CYPs) sont des hémoprotéines intervenant dans la fonction de détoxication cel...
Cytochrome P450 enzymes (CYPs) are the largest group of enzymes involved in human drug metabolism. L...
Cytochrome P450 enzymes (CYPs) are the largest group of enzymes involved in human drug metabolism. L...
Includes bibliographical references.Cytochrome P450 (CYPs) are a superfamily of heme containing enzy...
The human cytochrome P450 enzymes (CYPs) are heme-protein monooxygenases, which catalyze oxidative r...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
Although the majority of enzymes have buried active sites, very little is known about the energetics...
Although the majority of enzymes have buried active sites, very little is known about the energetics...
Cytochromes P450 (CYP450s), in particular, CYP19A1 and CYP17A1, are key clinical targets of breast a...
The cytochromes P450s (CYPs) are hemoproteins involved in the cellular detoxification function. The ...
Les cytochromes P450s (CYPs) sont des hémoprotéines intervenant dans la fonction de détoxication cel...
Les cytochromes P450s (CYPs) sont des hémoprotéines intervenant dans la fonction de détoxication cel...
Les cytochromes P450s (CYPs) sont des hémoprotéines intervenant dans la fonction de détoxication cel...
Cytochrome P450 enzymes (CYPs) are the largest group of enzymes involved in human drug metabolism. L...
Cytochrome P450 enzymes (CYPs) are the largest group of enzymes involved in human drug metabolism. L...
Includes bibliographical references.Cytochrome P450 (CYPs) are a superfamily of heme containing enzy...
The human cytochrome P450 enzymes (CYPs) are heme-protein monooxygenases, which catalyze oxidative r...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, ...
Although the majority of enzymes have buried active sites, very little is known about the energetics...
Although the majority of enzymes have buried active sites, very little is known about the energetics...
Cytochromes P450 (CYP450s), in particular, CYP19A1 and CYP17A1, are key clinical targets of breast a...