Gastric Cancer

BackgroundHistorically, foreign-born individuals in the US have had an elevated risk of dying from gastric cancer when compared to US-born individuals. This is primarily due to factors that occur prior to their immigration to the US, including diet and underlying risk of H. pylori infection.MethodsNational mortality data from 2005 to 2014 were obtained from the CDC\u2019s National Center for Health Statistics. Annual population estimates were obtained from the US Census Bureau\u2019s American Community Survey for foreign-born and US-born persons. Age-adjusted gastric cancer mortality rates and rate ratios (RR) were calculated stratified by birth place, age, race/ethnicity, and geographic location.ResultsFrom 2005 to 2014, 111,718 deaths from malignant gastric cancer occurred in the US, of which 24,583 (22%) occurred among foreign-born individuals. Overall, foreign-born individuals had higher mortality rates compared with US- born individuals (RR 1.82; 95% CI 1.80, 1.85) and this difference remained after stratifying by sex, age, and geographic location. However, this finding was primarily driven by the low rate of gastric cancer mortality among US-born whites, with similar mortality rates observed among all other foreign-born and US-born groups. Gastric cancer mortality rates significantly decreased during the study period overall (AAPC 12 2.50; 95% CI 12 3.21, 12 1.79) with significant declines observed among US-born (AAPC 12 2.81; 95% CI 12 3.55, 12 2.07) and the foreign-born (AAPC 12 2.53; 95% CI 12 3.20, 12 1.86) population.ConclusionsEfforts directed at reducing the prevalence of gastric cancer risk factors could help reduce the elevated burden observed among foreign-born individuals and US-born minority groups.20192020-09-01T00:00:00ZCC999999/Intramural CDC HHS/United States30830640PMC6697193828