Synergistic cytotoxicity of vitamins C and K3 towards rat glioma C6 cells in vitro

Malignant glioma is the most common primary CNS tumour [1]. Glioblastoma is an incurable brain tumor that usually causes death within 2 years after conventional therapies consisting of surgery, radiation, and chemotherapy [2]. The development of more potent and less toxic compounds represents one of the major goals to overwhelm the poor outcome of patients with glioblastoma [3]. It has been shown that the combination of vitamins C and K3 at the ratio 100:1 is synergistic towards some tumour cell lines in vitro [4]. The aim of this study was to study the cytotoxic action of vitamins C and K3 in vitro and find out whether the action of these vitamins is synergistic for rat glioma C6 cells. [...]Biologijos katedraKauno medicinos universitetasVytauto Didžiojo universiteta