Impact of toxicological exposure, hypertension and angiotensin converting enzyme polymorphism of women on birth outcomes

Some evidence suggests that a variety of genetic factors contributed in pathogenesis of the hypertension and pregnancy preeclampsia. Maternal hypertension is associated with adverse pregnancy outcomes, including preterm birth and low birth weight. Angiotensin converting enzyme (ACE) is a key factor in renin-angiotensin-aldosterone hormonal system, which is an important factor in development of hypertension. Impact of toxicological factors and angiotensin converting enzyme polymorphism of pregnant women with hypertension (blood pressure ≥140/90 mmHg) (121) and control group with normal blood pressure (187) in Kaunas (Lithuania) were investigated. The I/D polymorphism of the ACE gene was assessed by polymerase chain reaction. Multivariate logistic regression model was used to estimate odds ratios (ORs) and 95-percent confidence intervals (CIs) for hypertension and the maternal genotypes. The study results showed that the ACE D and I allele frequencies in two woman groups were similar, D – 0.503, I – 0.497. The frequency of ACE Insertion/Deletion (ID) genotype in pregnant woman with high blood pressure (≥140/90 mmHg) group (62,8%) was significantly (p=0.006) higher than in controls (44.4%). The study revealed that ACE ID genotype increases the risk of hypertension (blood pressure ≥140/90 mmHg) OR 2.05 (95% PI 1.09–3.86). The association between the ACE I/D gene polymorphism with hypertension in reproductive age women exposed to different toxicological factors (air pollutant, smoking, water quality) on birth outcomes were analyzedAplinkotyros katedraBiologijos katedraVytauto Didžiojo universiteta