It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investigate this hypothesis, we administered a probabilistic reversal learning task (ProbRev) to OCD patients, their unaffected first-degree relatives, and healthy controls. Although the relatives had a performance in between OCDs and controls at the early phase of the ProbRev, their performance was similar to controls and was significantly better than OCD patients at the later stages of the test. Our findings imply that reversal learning impairment might be partly a trait-related feature of OCD but state-related factors can also contribute to observed deficits
Alterations in frontal and parietal neural activations during working memory task performance have b...
CONTEXT: The orbitofrontal cortex (OFC)-striatal circuit, which is important for motivational behavi...
Although individuals with schizophrenia show impaired feedback-driven learning on probabilistic reve...
It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investiga...
It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investiga...
Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized ...
5siObsessive and compulsive symptoms are only partially explained by current cognitive-behavioral mo...
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated...
Cognitive dysfunctions such as inhibitory deficits and visuospatial abnormalities are often found in...
Objectives Reversal learning (RL) is impaired in obsessive–compulsive disorder (OCD) as well as in m...
Introduction: It has been theorized that endophenotype models will help to understand the etiology o...
In this chapter, I address the concept of endophenotypes for obsessive-compulsive disorder (OCD). En...
RATIONALE: Obsessive-compulsive disorder (OCD) implicates dysfunction of orbitofrontal and insula-re...
BACKGROUND: Several lines of research suggest a disturbance of reversal learning (reward and punishm...
Background. Patients with obsessive-compulsive disorder (OCD) have to repeat their actions before fe...
Alterations in frontal and parietal neural activations during working memory task performance have b...
CONTEXT: The orbitofrontal cortex (OFC)-striatal circuit, which is important for motivational behavi...
Although individuals with schizophrenia show impaired feedback-driven learning on probabilistic reve...
It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investiga...
It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investiga...
Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized ...
5siObsessive and compulsive symptoms are only partially explained by current cognitive-behavioral mo...
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated...
Cognitive dysfunctions such as inhibitory deficits and visuospatial abnormalities are often found in...
Objectives Reversal learning (RL) is impaired in obsessive–compulsive disorder (OCD) as well as in m...
Introduction: It has been theorized that endophenotype models will help to understand the etiology o...
In this chapter, I address the concept of endophenotypes for obsessive-compulsive disorder (OCD). En...
RATIONALE: Obsessive-compulsive disorder (OCD) implicates dysfunction of orbitofrontal and insula-re...
BACKGROUND: Several lines of research suggest a disturbance of reversal learning (reward and punishm...
Background. Patients with obsessive-compulsive disorder (OCD) have to repeat their actions before fe...
Alterations in frontal and parietal neural activations during working memory task performance have b...
CONTEXT: The orbitofrontal cortex (OFC)-striatal circuit, which is important for motivational behavi...
Although individuals with schizophrenia show impaired feedback-driven learning on probabilistic reve...