A role of leptin in psoriasis?

Aim: Although there is evidence of a positive association between psoriasis and body mass index (BMI) and leptin is known to play a part in the regulation of the immune system, the relationship between psoriasis and leptin is still not well known. The aim of this study was to evaluate the possible relation between leptin and psoriasis. Materials and Methods: Serum leptin concentrations and BMI in 20 patients with psoriasis were compared to 20 age- and sex-matched healthy volunteers. Results: There was no difference between serum leptin levels of psoriatic patients (32.3 ± 24.9 ng/ml) and controls (36.8 ± 28.2 ng/ml). Leptin levels of both psoriatic and healthy volunteers showed positive correlations with BMI. Serum leptin levels in the patient group did not correlate with psoriasis area severity index (PASI) score or duration of psoriasis. Conclusions: In the setting of this study, our results did not support any possible relation between serum leptin levels and psoriasis. © TÜBİTAK