Multicentre evaluation of the Roche Elecsys® Active B12 (holotranscobalamin) electro-chemiluminescence immunoassay
- Heil, S.G. (Sandra)
- Bodenburg, P. (Petra)
- Findeisen, P. (Peter)
- Luebcke, S. (Silke)
- Sun, Y. (Yuli)
- Rijke, Y.B. (Yolanda) de
DOIAbstract
Background: Vitamin B12 deficiency is a common disorder. In circulation, vitamin B12 is bound to transcobalamin (holotranscobalamin), which is considered the active form of cobalamin. The objective of this study was to evaluate the analytical performance of the Roche Elecsys Active B12 immunoassay. Methods: Limit of quantification and linearity were assessed according to CLSI EP17-A2 and EP-6A guidelines. Precision and bias of Roche Active B12 test against Architect ci8200 (Abbott) were performed according to CLSI EP-5 A3 guideline at three Euro
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