Aberrant microRNA expression and its implications for uveal melanoma metastasis
- Smit, K.N. (Kyra)
- Chang, J. (Jiang)
- Derks, K.W.J. (Kasper)
- Vaarwater, J. (Jolanda)
- Brands, T. (Tom)
- Verdijk, R.M. (Robert)
- Wiemer, E.A.C. (Erik)
- Mensink, H.W. (Hanneke)
- Pothof, J. (Joris)
- Klein, A. (Annelies) de
- Kiliç, E. (Emine)
DOIAbstract
Uveal melanoma (UM) is the most frequently found primary intra-ocular tumor in adults. It is a highly aggressive cancer that causes metastasis-related mortality in up to half of the patients. Many independent studies have reported somatic genetic changes associated with high metastatic risk, such as monosomy of chromosome 3 and mutations in BAP1. Still, the mechanisms that drive metastatic spread are largely unknown
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