DALI: Defining antibiotic levels in intensive care unit patients: Are current ß-lactam antibiotic doses sufficient for critically ill patients?
- Roberts, J. A.
- Paul, S. K.
- Akova, M.
- Bassetti, M.
- De Waele, J. J.
- Dimopoulos, G.
- Kaukonen, K. -M.
- Koulenti, D.
- Martin, C.
- Montravers, P.
- Rello, J.
- Rhodes, A.
- Starr, T.
- Wallis, S. C.
- Lipman, J.
- Margarit Ribas, A.
- De Crop, L.
- Spapen, H.
- Wauters, J.
- Dugernier, T.
- Jorens, P.
- Dapper, I.
- De Backer, D.
- Taccone, F. S.
- Ruano, L.
- Afonso, E.
- Alvarez-Lerma, F.
- Gracia-Arnillas, M. P.
- Fernández, F.
- Feijoo, N.
- Bardolet, N.
- Rovira, A.
- Garro, P.
- Colon, D.
- Castillo, C.
- Fernado, J.
- Lopez, M. J.
- Fernandez, J. L.
- Arribas, A. M.
- Teja, J. L.
- Ots, E.
- Carlos Montejo, J.
- Catalan, M.
- Prieto, I.
- Gonzalo, G.
- Galvan, B.
- Blasco, M. A.
- Meyer, E.
- Del Nogal, F.
- Vidaur, L.
- Sebastian, R.
- Garde, P. M.
- Martin Velasco, M. D. M.
- Zaragoza Crespo, R.
- Esperatti, M.
- Torres, A.
- Baldesi, O.
- Dupont, H.
- Mahjoub, Y.
- Lasocki, S.
- Constantin, J. M.
- Payen, J. F.
- Albanese, J.
- Malledant, Y.
- Pottecher, J.
- Lefrant, J. -Y.
- Jaber, S.
- Joannes-Boyau, O.
- Orban, C.
- Ostermann, M.
- McKenzie, C.
- Berry, W.
- Smith, J.
- Lei, K.
- Rubulotta, F.
- Gordon, A.
- Brett, S.
- Stotz, M.
- Templeton, M.
- Ebm, C.
- Moran, C.
- Pettilä, V.
- Xristodoulou, A.
- Theodorou, V.
- Kouliatsis, G.
- Sertaridou, E.
- Anthopoulos, G.
- Choutas, G.
- Rantis, T.
- Karatzas, S.
- Balla, M.
- Papanikolaou, M.
- Myrianthefs, P.
- Gavala, A.
- Fildisis, G.
- Koutsoukou, A.
- Kyriakopoulou, M.
- Petrochilou, K.
- Kompoti, M.
- Michalia, M.
- Clouva-Molyvdas, F. -M.
- Gkiokas, G.
- Nikolakopoulos, F.
- Psychogiou, V.
- Malliotakis, P.
- Akoumianaki, E.
- Lilitsis, E.
- Koulouras, V.
- Nakos, G.
- Kalogirou, M.
- Komnos, A.
- Zafeiridis, T.
- Chaintoutis, C.
- Arvaniti, K.
- Matamis, D.
- Kydona, C.
- Gritsi-Gerogianni, N.
- Giasnetsova, T.
- Giannakou, M.
- Soultati, I.
- Chytas, I.
- Antoniadou, E.
- Antipa, E.
- Lathyris, D.
- Koukoubani, T.
- Paraforou, T.
- Spiropoulou, K.
- Bekos, V.
- Spring, A.
- Kalatzi, T.
- Nikolaou, H.
- Laskou, M.
- Strouvalis, I.
- Aloizos, S.
- Kapogiannis, S.
- Soldatou, O.
- Adembri, C.
- Villa, G.
- Giarratano, A.
- Maurizio Raineri, S.
- Cortegiani, A.
- Montalto, F.
- Strano, M. T.
- Ranieri, V. M.
- Sandroni, C.
- De Pascale, G.
- Molin, A.
- Pelosi, P.
- Montagnani, L.
- Urbino, R.
- Mastromauro, I.
- De Rosa, F. G.
- Cardoso, T.
- Afonso, S.
- Gonçalves-Pereira, J.
- Baptista, J. P.
- Özveren, A.
DOIAbstract
Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether α-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.Methods. This was a prospective, multinational pharmacokinetic point-prevalence study including 8 α-lactam antibiotics. Two blood samples were taken from each patient during a single dosing interval. The primary pharmacokinetic/pharmacodynamic targets were free antibiotic concentrations above the minimum inhibitory concentration (MIC) of the pathogen at both 50% (50% f TMIC) and 100% (100% f T MIC) of the dosing interval. We us...
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