Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
- Berndt, S.I.
- Camp, N.J.
- Skibola, C.F.
- Vijai, J.
- Wang, Z.
- Gu, J.
- Nieters, A.
- Kelly, R.S.
- Smedby, K.E.
- Monnereau, A.
- Cozen, W.
- Cox, A.
- Wang, S.S.
- Lan, Q.
- Teras, L.R.
- Machado, M.
- Yeager, M.
- Brooks-Wilson, A.R.
- Hartge, P.
- Purdue, M.P.
- Birmann, B.M.
- Vajdic, C.M.
- Cocco, P.
- Zhang, Y.
- Giles, G.G.
- Zeleniuch-Jacquotte, A.
- Lawrence, C.
- Montalvan, R.
- Burdett, L.
- Hutchinson, A.
- Ye, Y.
- Call, T.G.
- Shanafelt, T.D.
- Novak, A.J.
- Kay, N.E.
- Liebow, M.
- Cunningham, J.M.
- Allmer, C.
- Hjalgrim, H.
- Adami, H.-O.
- Melbye, M.
- Glimelius, B.
- Chang, E.T.
- Glenn, M.
- Curtin, K.
- Cannon-Albright, L.A.
- Diver, W.R.
- Link, B.K.
- Weiner, G.J.
- Conde, L.
- Bracci, P.M.
- Riby, J.
- Arnett, D.K.
- Zhi, D.
- Leach, J.M.
- Holly, E.A.
- Jackson, R.D.
- Tinker, L.F.
- Benavente, Y.
- Sala, N.
- Casabonne, D.
- Becker, N.
- Boffetta, P.
- Brennan, P.
- Foretova, L.
- Maynadie, M.
- McKay, J.
- Staines, A.
- Chaffee, K.G.
- Achenbach, S.J.
- Vachon, C.M.
- Goldin, L.R.
- Strom, S.S.
- Leis, J.F.
- Weinberg, J.B.
- Caporaso, N.E.
- Norman, A.D.
- De Roos, A.J.
- Morton, L.M.
- Severson, R.K.
- Riboli, E.
- Vineis, P.
- Kaaks, R.
- Masala, G.
- Weiderpass, E.
- Chirlaque, M.-D.
- Vermeulen, R.C.H.
- Travis, R.C.
- Southey, M.C.
- Milne, R.L.
- Albanes, D.
- Virtamo, J.
- Weinstein, S.
- Clavel, J.
- Zheng, T.
- Holford, T.R.
- Villano, D.J.
- Maria, A.
- Spinelli, J.J.
- Gascoyne, R.D.
- Connors, J.M.
- Bertrand, K.A.
- Giovannucci, E.
- Kraft, P.
- Kricker, A.
- Turner, J.
- Ennas, M.G.
- Ferri, G.M.
- Miligi, L.
- Liang, L.
- Ma, B.
- Huang, J.
- Crouch, S.
- Park, J.-H.
- Chatterjee, N.
- North, K.E.
- Snowden, J.A.
- Wright, J.
- Fraumeni, J.F.
- Offit, K.
- Wu, X.
- De Sanjose, S.
- Cerhan, J.R.
- Chanock, S.J.
- Rothman, N.
- Slager, S.L.
DOIAbstract
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 7 10-11), 6p25.2 (rs73718779, SERPINB6, P=1.97 7 10-8) and 3q28 (rs9815073, LPP, P=3.62 7 10-8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 7 10-11) in the combined analysis. We find suggestive evidence (P<5 7 10-7) for two additional new loci at 4q24 (rs1...
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