Rapid cosmetic improvements in nail psoriasis patients treated with K101-03

Background Nail psoriasis can cause embarrassment and stigmatization. A therapy that produces rapid cosmetic improvements could therefore make a difference to patients. Objectives Data from an 8\u2011week open-label multicenter study were analyzed to assess the efficacy of K101-03, a Nail psoriasis containing propylene glycol, glycerol, urea and lactic acid, in adult patients with nail psoriasis. Patients and Methods Patients (n=35) applied K101-03 to their affected nails once daily for 8 weeks. They rated the overall appearance of a selected nail (the \u201ctarget\u201d nail) versus baseline on a 4\u2011point scale after 1, 2, 4 and 8 weeks of treatment. At the same time points, they also assessed whether, compared to baseline, the target nail was less thickened, less discolored, less brittle and softer. Results After 8 weeks of K101\u201103 treatment, the overall appearance of the target nail was improved in 94.1% of patients (95% confidence interval [CI] 86.2\u2013100). After 1 week of treatment, 70.6% of patients (95% CI 55.3\u201385.9) reported an overall improvement in the target nail and 52.9% of them reported that their target nail was less discolored. Three\u2011quarters of patients reported softening of their target nail after 8 weeks of treatment. Conclusion In summary, K101-03 rapidly improved the appearance and other physical attributes of nails affected by psoriasis