Chronic hepatitis B in Italy: New features of an old disease - Approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection
- Sagnelli, Evangelista
- Stroffolini, Tommaso
- Mele, Alfonso
- Imparato, Michele
- Almasio, Piero L.
- Traverso, A.
- Arrigoni, A.
- Torchio, M.
- Garbagnoli, P.
- Del Mastro, B.
- Romano, P.
- Vanni, R.
- Brusita, D.
- Meucci, P.
- Cassola, G.
- Borzio, M.
- Bellobuono, A.
- De Bona, A.
- Re, T.
- Del Poggio, P.
- Baisini, O.
- Colombo, A.
- Attolini, C.
- Sacchini, D.
- Minoli, L.
- Gazzaniga, V.
- Segato, S.
- Oriolo, M.
- Parlotto, A.
- Ghersetti, M.
- Capra, F.
- Muratori, R.
- Sama, C.
- Boccia, S.
- Verdianelli, G.
- Praticò, A.
- Grandi, M.
- Ventura, E.
- Cantoni, F.
- Vincenti, A.
- Nerli Alessandro, A.
- Galeazzi, L.
- Solinas, A.
- Paroli, M.
- De Sanctis, G. M.
- Sereno, S.
- Clementi, C.
- Visco Comandino, U.
- Gallo, A. I.
- Festi, D.
- Sabusco, G.
- Coppola, N.
- Scolastico, C.
- Onofrio, M.
- Filippini, P.
- Morisco, F.
- Liberti, A.
- Borgia, G.
- Scarpellino, F.
- Persico, M.
- Sagnelli, C.
- Coppola, C.
- Caserta, L.
- Elia, A.
- De Vita, G.
- Lanzotti, A.
- Pizzolante, L.
- Messina, V.
- Fiore, G.
- Agostinacchio, E.
- Santantonio, T.
- Mazzola, M.
- Vinelli, F.
- Campagna, A.
- Cataldini, S.
- Monelli, I.
- Lascaro, M.
- Polimeri, N.
- Frugiuele, P.
- Ferraro, M.
- Prestileo, T.
- Alessandri, A.
- Russello, M.
- Bellissima, P.
- Orifici, G.
- Pisani, G.
- Angioini, S.
- Lai, M.
- Spanneda, M.
Publication date
January 2008
DOIAbstract
We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis. © 2007 by the Infectious Diseases Society of America. All rights reserved
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