Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

open12noWerner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the molecular alterations that lead to disease phenotype remain still unidentified.This study was supported by the European Union ’s Seventh Framework Programme [grant number 602757 ( “HUMAN: Health and the understanding of Metabolism, Aging and Nutrition ”)] and by the European Union’s H2020Project [grant number 634821 (“PROPAG-AGEING: The continuum between healthy ageing and idiopathic Parkinson Disease within a propagationperspective of inflammation and damage: the search for new diagnostic,prognostic and therapeutic targets”) and JPco-fuND (ADAGE: Alzheimer Disease pathology within the ageing physiology”)].openGuastafierro, T; Bacalini, MG; Marcoccia, A; Gentilini, D; Pisoni, S; Di Blasio, A M; Corsi, A; Franceschi, C; Raimondo, D; Spanò, A; Garagnani, P; Bondanini, FGuastafierro, T; Bacalini, MG; Marcoccia, A; Gentilini, D; Pisoni, S; Di Blasio, A M; Corsi, A; Franceschi, C; Raimondo, D; Spanò, A; Garagnani, P; Bondanini,