Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro E.
Betari N.
Arencibia J. M.
Montanari S.
Sissi C.
De Simone A.
Vassura I.
Santini A.
Andrisano V.
Tumiatti V.
De Vivo M.
Krysko D. V.
Rocchi M. B. L.
Fimognari C.
Milelli A.

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

August 2020

none15siDrugs targeting human topoisomerase II (topoII) are used in clinical practice since decades....

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase II? Poisons and Cytotoxic Agents

Zagotto, Giuseppe
Alessandra, Gianoncelli
Sissi, Claudia
Marzano, Cristina
Gandin, Valentina
Riccardo, Pasquale
Giovanni, Capranico
Ribaudo, Giovanni
Palumbo, Manlio

January 2014

The precise definition of the structural requirements for effective topoisomerase II poisoning by dr...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, Jose Antonio
Riccardi, Laura
Minniti, Elirosa
Borgogno, Marco
Arencibia, Jose M.
Greco, Maria L.
Minarini, Anna
Sissi, Claudia
De Vivo, Marco

January 2018

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and e...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, Jose Antonio
Riccardi, Laura
Minniti, Elirosa
Borgogno, Marco
Arencibia, Jose M
Greco, Maria L
Minarini, Anna
Sissi, Claudia
De Vivo, Marco

January 2018

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and e...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, Jose Antonio
Riccardi, Laura
Minniti, Elirosa
Borgogno, Marco
Arencibia, Jose M
Greco, Maria L
Minarini, Anna
Sissi, Claudia
De Vivo, Marco

January 2018

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and e...

MUTAGENICITY OF SOME TOPOISOMERASE II-INTERACTIVE AGENTS

Sabry M. Attia

December 2014

Among the anticancer drugs currently used in the treatment of human malignancies, as well as several...

Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

Fayad Walid
Fryknäs Mårten
Brnjic Slavica
Olofsson Maria Hägg
Larsson Rolf
Linder Stig

October 2009

Natural product structures have high chemical diversity and are attractive as lead structures for di...

Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

Fayad Walid
Fryknäs Mårten
Brnjic Slavica
Olofsson Maria Hägg
Larsson Rolf
Linder Stig

October 2009

Natural product structures have high chemical diversity and are attractive as lead structures for di...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro E.
Betari N.
Arencibia J. M.
Montanari S.
Sissi C.
De Simone A.
Vassura I.
Santini A.
Andrisano V.
Tumiatti V.
De Vivo M.
Krysko D. V.
Rocchi M. B. L.
Fimognari C.
Milelli A.

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro E.
Betari N.
Arencibia J. M.
Montanari S.
Sissi C.
De Simone A.
Vassura I.
Santini A.
Andrisano V.
Tumiatti V.
De Vivo M.
Krysko D. V.
Rocchi M. B. L.
Fimognari C.
Milelli A.

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

August 2020

none15siDrugs targeting human topoisomerase II (topoII) are used in clinical practice since decades....

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase II? Poisons and Cytotoxic Agents

Zagotto, Giuseppe
Alessandra, Gianoncelli
Sissi, Claudia
Marzano, Cristina
Gandin, Valentina
Riccardo, Pasquale
Giovanni, Capranico
Ribaudo, Giovanni
Palumbo, Manlio

January 2014

The precise definition of the structural requirements for effective topoisomerase II poisoning by dr...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, Jose Antonio
Riccardi, Laura
Minniti, Elirosa
Borgogno, Marco
Arencibia, Jose M.
Greco, Maria L.
Minarini, Anna
Sissi, Claudia
De Vivo, Marco

January 2018

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and e...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, Jose Antonio
Riccardi, Laura
Minniti, Elirosa
Borgogno, Marco
Arencibia, Jose M
Greco, Maria L
Minarini, Anna
Sissi, Claudia
De Vivo, Marco

January 2018

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and e...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, Jose Antonio
Riccardi, Laura
Minniti, Elirosa
Borgogno, Marco
Arencibia, Jose M
Greco, Maria L
Minarini, Anna
Sissi, Claudia
De Vivo, Marco

January 2018

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and e...

MUTAGENICITY OF SOME TOPOISOMERASE II-INTERACTIVE AGENTS

Sabry M. Attia

December 2014

Among the anticancer drugs currently used in the treatment of human malignancies, as well as several...

Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

Fayad Walid
Fryknäs Mårten
Brnjic Slavica
Olofsson Maria Hägg
Larsson Rolf
Linder Stig

October 2009

Natural product structures have high chemical diversity and are attractive as lead structures for di...

Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

Fayad Walid
Fryknäs Mårten
Brnjic Slavica
Olofsson Maria Hägg
Larsson Rolf
Linder Stig

October 2009

Natural product structures have high chemical diversity and are attractive as lead structures for di...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro E.
Betari N.
Arencibia J. M.
Montanari S.
Sissi C.
De Simone A.
Vassura I.
Santini A.
Andrisano V.
Tumiatti V.
De Vivo M.
Krysko D. V.
Rocchi M. B. L.
Fimognari C.
Milelli A.

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro, Elena
Betari, Nibal
Arencibia, Jose M
Montanari, Serena
Sissi, Claudia
De Simone, Angela
Vassura, Ivano
Santini, Alan
Andrisano, Vincenza
Tumiatti, Vincenzo
De Vivo, Marco
Krysko, Dmitri V
Rocchi, Marco Bruno Luigi
Fimognari, Carmela
Milelli, Andrea

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

Catanzaro E.
Betari N.
Arencibia J. M.
Montanari S.
Sissi C.
De Simone A.
Vassura I.
Santini A.
Andrisano V.
Tumiatti V.
De Vivo M.
Krysko D. V.
Rocchi M. B. L.
Fimognari C.
Milelli A.

January 2020

Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Neverth...

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

August 2020

none15siDrugs targeting human topoisomerase II (topoII) are used in clinical practice since decades....

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase II? Poisons and Cytotoxic Agents

Zagotto, Giuseppe
Alessandra, Gianoncelli
Sissi, Claudia
Marzano, Cristina
Gandin, Valentina
Riccardo, Pasquale
Giovanni, Capranico
Ribaudo, Giovanni
Palumbo, Manlio

January 2014

The precise definition of the structural requirements for effective topoisomerase II poisoning by dr...

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Abstract

Extracted data

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Abstract

Extracted data

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