Gold-Catalyzed Dearomatization of 2-Naphthols with Alkynes

none6siThe site-selective dearomatization of naphthols is realized in astraightforward manner through a gold(I)- catalyzed [3,3]-sigmatropic rearrangement/allene function- alizationcascade sequence. The methodemploys readily available naph thylpropargyl ethers as startingmaterials. A range of denselyfunctionalized dihydrofurylnaphthalen-2(1H)-ones are obtained in high yields (up to 98 %) and extremely mild reactionconditions (reagent grade solvent, air,10 minute reaction time). Acomplete theoretical eluci- dation of the reaction machinery is also proposed, providing arationalefor important issues such as regio- and chemoselectivity.mixedJuzeng, An; Adriano, Parodi; Magda, Monari; Marta Castineira Reis, ; Carlos Silva Lopez, ; Marco, BandiniJuzeng, An; Adriano, Parodi; Magda, Monari; Marta Castineira Reis, ; Carlos Silva Lopez, ; Marco, Bandin