Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging
- MONACO, ILARIA
- Arena, Francesca
- Biffi, Stefania
- LOCATELLI, ERICA
- Bortot, Barbara
- La Cava, Francesca
- Marini, Giada Maria
- Severini, Giovanni Maria
- Terreno, Enzo
- COMES FRANCHINI, MAURO
Publication date
January 2017
DOI ISSN
1043-1802 Language
English Citation count (estimate)
17Abstract
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer
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