In this paper, a new mixed nonuniform Transformation Field Analysis (TFA) homogenization technique for deriving the overall mechanical response of heterogeneous materials is proposed. The new TFA approach is based on a mixed stress variational formulation of the elasto-plasticity theory, assuming stresses and plastic multiplier as independent variables. The case of periodic composites is considered, so that the homogenization is performed on a repetitive unit cell that plays the equivalent role of representative volume element for random media. The unit cell of the material is divided into subsets and in each subset the weak form of the compatibility condition and of the consistency condition are enforced, leading to a simultaneous evaluati...