Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors
- PANTALEO, MARIA ABBONDANZA
- RAVEGNINI, GLORIA
- ASTOLFI, ANNALISA
- NANNINI, MARGHERITA
- SAPONARA, MARISTELLA
- URBINI, MILENA
- GATTO, LIDIA
- INDIO, VALENTINA
- SAMMARINI, GIULIA
- SANTINI, DONATELLA
- FERRACIN, MANUELA
- HRELIA, PATRIZIA
- BIASCO, GUIDO
- ANGELINI, SABRINA
- Simeon, Vittorio
- Negrini, Massimo
Publication date
January 2016
DOIAbstract
Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). This prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients
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