Next Generation Sequencing and Linkage Analysis for the Molecular Diagnosis of a Novel Overlapping Syndrome Characterized by Hypertrophic Cardiomyopathy and Typical Electrical Instability of Brugada Syndrome

none11noFamilial hypertrophic cardiomyopathy (HCM) is an autosomal dominant inherited disorder; mutations in at least 20 genes have been associated. Brugada syndrome (BrS) is an autosomal dominant inherited disorder caused by mutations mainly in theSCN5Agene. A new clinical entity that consists of HCM, typical electrical instability of BrS and sudden death (SD), is described.mixedMango, Ruggiero; Luchetti, Andrea; Sangiuolo, Raffaele; Ferradini, Valentina; Briglia, Nicola; Giardina, Emiliano; Ferrè, Fabrizio; Helmer Citterich, Manuela; Romeo, Francesco; Novelli, Giuseppe; Sangiuolo, FedericaMango, Ruggiero; Luchetti, Andrea; Sangiuolo, Raffaele; Ferradini, Valentina; Briglia, Nicola; Giardina, Emiliano; Ferrè, Fabrizio; Helmer Citterich, Manuela; Romeo, Francesco; Novelli, Giuseppe; Sangiuolo, Federic