Bone metastases impair general health status, quality of life and survival of patients. Electrochemotherapy (ECT), which combines electroporation (EP) and the administration of anticancer drugs, has been recently introduced into clinical practice for the local treatment of solid tumours. In the present study, the ability of EP with bleomycin (Bleo) to induce MRMT-1 rat breast cancer cell death was investigated in vitro. Then, an in vivo model for bone metastases was set up by the inoculation of MRMT-1 cells in rat proximal tibia. 7 days after tumour induction the animals were treated with Bleo, EP, Bleo followed by EP (ECT), or left untreated. ECT eliminated the tumour in 6 out of 8 (75 %) treated metastases. Radiological evaluation showed ...
Goal of the study is to extablish the values of parameners of electroporation above which, in the tr...
Electrochemical treatment (EChT) with direct current delivered through implanted electrodes has been...
Background: Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young...
Bone metastases impair general health status, quality of life and survival of patients. Electrochemo...
Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order ...
none4noIntroduction: Bone metastatic disease is a major cause of pain and decreased quality of life ...
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a m...
Background : Electrochemotherapy is an unique treatment to enhance the drug permeability of tumor ce...
Purpose – Electrochemotherapy (ECT) is an outstanding technique for treatment of tumor nodules which...
Skeletal metastases are a common cause of severe morbidity, reduction in quality of life and often e...
Short intense electrical pulses transiently increase the permeability of the cell membrane, an effec...
Electroporation is used to enhance drug diffusion and gene delivery into the cytosol. The combinatio...
Electrochemotherapy (ECT) has emerged among European centers as an innovative locoregional treatment...
Goal of the study is to extablish the values of parameners of electroporation above which, in the tr...
Electrochemical treatment (EChT) with direct current delivered through implanted electrodes has been...
Background: Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young...
Bone metastases impair general health status, quality of life and survival of patients. Electrochemo...
Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order ...
none4noIntroduction: Bone metastatic disease is a major cause of pain and decreased quality of life ...
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a m...
Background : Electrochemotherapy is an unique treatment to enhance the drug permeability of tumor ce...
Purpose – Electrochemotherapy (ECT) is an outstanding technique for treatment of tumor nodules which...
Skeletal metastases are a common cause of severe morbidity, reduction in quality of life and often e...
Short intense electrical pulses transiently increase the permeability of the cell membrane, an effec...
Electroporation is used to enhance drug diffusion and gene delivery into the cytosol. The combinatio...
Electrochemotherapy (ECT) has emerged among European centers as an innovative locoregional treatment...
Goal of the study is to extablish the values of parameners of electroporation above which, in the tr...
Electrochemical treatment (EChT) with direct current delivered through implanted electrodes has been...
Background: Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young...