UNFRACTIONED HEPARIN/CLOPIDOGREL INTERACTION IN PATIENTS WITH STEMI NOT UNDERGOING REPERFUSION

Background: A substantial proportion of patients with ST-segment elevation myocardial infarction (STEMI) do not receive reperfusion therapy.The aim of our study was to investigate the relative benefits of enoxaparine compared to unfractioned heparin (UFH) in association with clopidogrel in STEMI patients not undergoing reperfusion therapy. Methods: We enrolled 1440 consecutive patients with STEMI from 2007 to 2011. A total of 584 patients (40.6 %) did not receive reperfusion therapy. At admission, 223 were treated with enoxaparine and 292 patients with UFH. All patients received aspirin and/or clopidogrel. No significant differences were found in the concomitant medications between the group treated with enoxaparine compared to UFH treated patients. Results: We found a significant interaction (p