SET-UP OF A MULTIPLEX PCR TO RAPIDLY DETECT IKZF1 (IKAROS) GENE BREAKPOINT DELETION IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?

C. Palmi
M. G. Valsecchi
G. Longinotti
D. Silvestri
V. Carrino
V. Conter
A. Biondi
TE KRONNIE, GEERTRUDY
G. Cazzaniga
BASSO, GIUSEPPE

January 2013

New prognostic markers are needed for upfront identification of patients with acute lymphocytic leuk...

IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

July 2017

none24By genome-wide analyses of DNA copy number abnormalities in adult BCR-ABL1-positive ALL patien...

IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia

Iacobucci Ilaria
Iraci Nunzio
Messina Monica
Lonetti Annalisa
Chiaretti Sabina
Valli Emanuele
Ferrari Anna
Papayannidis Cristina
Paoloni Francesca
Vitale Antonella
Storlazzi Clelia Tiziana
Ottaviani Emanuela
Guadagnuolo Viviana
Durante Sandra
Vignetti Marco
Soverini Simona
Pane Fabrizio
Foà Robin
Baccarani Michele
Müschen Markus
Perini Giovanni
Martinelli Giovanni

July 2012

deletions by single nucleotide polymorphism (SNP) arrays; a sub-cohort of these patients (44%) was ...

MULTIPLEX PCR TO RAPIDLY IDENTIFY IKZF1 (IKAROS) GENE BREAKPOINTS IN BCRABL1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Ferrari A
Guadagnuolo V
Parisi S
Baccarani M
IACOBUCCI, ILARIA
LONETTI, ANNALISA
PAPAYANNIDIS, CRISTINA
ABBENANTE, MARIACHIARA
TRINO, STEFANIA
CATTINA, FEDERICA
PAOLINI, STEFANIA
MARTINELLI, GIOVANNI

January 2011

Background: Deletions of IKZF1 gene, encoding for a regulator of lymphocyte differentiation, occur i...

Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia

Caye, Aurélie
Beldjord, Kheïra
Mass-Malo, Kelly
Drunat, Séverine
Soulier, Jean
Gandemer, Virginie
Baruchel, André
Bertrand, Yves
Cavé, Hélène
Clappier, Emmanuelle

January 2013

International audienceDeletion of the Ikaros (IKZF1) gene is an oncogenic lesion frequently associat...

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)

Iacobucci, I
STORLAZZI, CLELIA TIZIANA
Cilloni, D
Lonetti, A
Ottaviani, E
Soverini, S
Astolfi, A
Chiaretti, S
Vitale, A
Messa, F
Impera, L
Baldazzi, C
D'ADDABBO, PIETRO
Papayannidis, C
Lonoce, A
Colarossi, S
Vignetti, M
Piccaluga, PP
Paolini, S
Russo, D
Pane, F
Saglio, G
Baccarani, M
Foa, R
Martinelli, G.

January 2009

The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL) with the worst c...

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).

I., Iacobucci
C. T., Storlazzi
D., Cilloni
A., Lonetti
E., Ottaviani
S., Soverini
A., Astolfi
Chiaretti, Sabina
A., Vitale
F., Messa
L., Impera
C., Baldazzi
P., D'Addabbo
C., Papayannidis
A., Lonoce
S., Colarossi
Vignetti, Marco
P. P., Piccaluga
S., Paolini
D., Russo
F., Pane
G., Saglio
M., Baccarani
Foa, Roberto
G., Martinelli

January 2009

The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL) with the worst c...

Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method.

July 2015

none24siBACKGROUND: Ikaros is the prototypic member of a Kruppel-like zinc finger transcription fact...

IKZF1 (Ikaros) Deletions in BCR-ABL1-Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report

MARTINELLI, GIOVANNI
IACOBUCCI, ILARIA
SOVERINI, SIMONA
PAPAYANNIDIS, CRISTINA
PAOLINI, STEFANIA
BACCARANI, MICHELE
Storlazzi CT
Vignetti M
Paoloni F
Cilloni D
Vitale A
Chiaretti S
Cimino G
Elia L
Fazi P
Meloni G
Amadori S
Saglio G
Pane F
Foà R.

January 2009

PURPOSE: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia...

Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia

Hashiguchi, Junichi
Onozawa, Masahiro
Oguri, Satoshi
Fujisawa, Shinichi
Tsuji, Masahisa
Okada, Kohei
Nakagawa, Masao
Hashimoto, Daigo
Kahata, Kaoru
Kondo, Takeshi
Shimizu, Chikara
Teshima, Takanori

July 2018

Intragenic deletion of IKZF1 is a recurrent genomic alteration in acute lymphoblastic leukemia. The ...

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report

Martinelli, Giovanni
I., Iacobucci
C. T., Storlazzi
Vignetti, Marco
F., Paoloni
D., Cilloni
S., Soverini
A., Vitale
Chiaretti, Sabina
Cimino, Giuseppe
C., Papayannidis
S., Paolini
L., Elia
P., Fazi
Meloni, Giovanna
S., Amadori
G., Saglio
F., Pane
M., Baccarani
Foa, Roberto

January 2009

Purpose: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia...

IKZF1 (IKAROS) DELETIONS IN BCR-ABL1 POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA ARE ASSOCIATED WITH AN IMPAIRED B-CELL DIFFERENTIATION AND POOR OUTCOME

July 2015

none25Introduction. The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukaemia (...

IKZF1 (IKAROS) DELETIONS ARE A CENTRAL EVENT IN THE PATHOGENESIS OF BCR-ABL1 POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

IACOBUCCI, ILARIA
OTTAVIANI, EMANUELA
LONETTI, ANNALISA
ASTOLFI, ANNALISA
TESTONI, NICOLETTA
BALDAZZI, CARMEN
SOVERINI, SIMONA
PAOLINI, STEFANIA
PAPAYANNIDIS, CRISTINA
MARTINELLI, GIOVANNI
Storlazzi T
Salmi F
Ferrari A
Impera L
Colarossi S
Gnani A
Piccaluga PP
Panagiota G
Cilloni D
Messa F
Pane
Vitale A
Chiaretti S
Foà R
Baccarani M

January 2008

The Philadelphia chromosome is the single most significant adverse prognostic marker in adult ALL. E...

IKZF1 (IKAROS) deletions as a prognostic marker in BCR-ABL1 positive acute lymphoblastic leukemia patients: A GIMEMA ALL WP Report

July 2017

none10Expression of BCR-ABL1 in hematopoietic stem cells can alone induce a chronic myeloid leukemia...

What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?

C. Palmi
M. G. Valsecchi
G. Longinotti
D. Silvestri
V. Carrino
V. Conter
A. Biondi
TE KRONNIE, GEERTRUDY
G. Cazzaniga
BASSO, GIUSEPPE

January 2013

New prognostic markers are needed for upfront identification of patients with acute lymphocytic leuk...

IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

July 2017

none24By genome-wide analyses of DNA copy number abnormalities in adult BCR-ABL1-positive ALL patien...

IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia

Iacobucci Ilaria
Iraci Nunzio
Messina Monica
Lonetti Annalisa
Chiaretti Sabina
Valli Emanuele
Ferrari Anna
Papayannidis Cristina
Paoloni Francesca
Vitale Antonella
Storlazzi Clelia Tiziana
Ottaviani Emanuela
Guadagnuolo Viviana
Durante Sandra
Vignetti Marco
Soverini Simona
Pane Fabrizio
Foà Robin
Baccarani Michele
Müschen Markus
Perini Giovanni
Martinelli Giovanni

July 2012

deletions by single nucleotide polymorphism (SNP) arrays; a sub-cohort of these patients (44%) was ...

MULTIPLEX PCR TO RAPIDLY IDENTIFY IKZF1 (IKAROS) GENE BREAKPOINTS IN BCRABL1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Ferrari A
Guadagnuolo V
Parisi S
Baccarani M
IACOBUCCI, ILARIA
LONETTI, ANNALISA
PAPAYANNIDIS, CRISTINA
ABBENANTE, MARIACHIARA
TRINO, STEFANIA
CATTINA, FEDERICA
PAOLINI, STEFANIA
MARTINELLI, GIOVANNI

January 2011

Background: Deletions of IKZF1 gene, encoding for a regulator of lymphocyte differentiation, occur i...

Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia

Caye, Aurélie
Beldjord, Kheïra
Mass-Malo, Kelly
Drunat, Séverine
Soulier, Jean
Gandemer, Virginie
Baruchel, André
Bertrand, Yves
Cavé, Hélène
Clappier, Emmanuelle

January 2013

International audienceDeletion of the Ikaros (IKZF1) gene is an oncogenic lesion frequently associat...

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)

Iacobucci, I
STORLAZZI, CLELIA TIZIANA
Cilloni, D
Lonetti, A
Ottaviani, E
Soverini, S
Astolfi, A
Chiaretti, S
Vitale, A
Messa, F
Impera, L
Baldazzi, C
D'ADDABBO, PIETRO
Papayannidis, C
Lonoce, A
Colarossi, S
Vignetti, M
Piccaluga, PP
Paolini, S
Russo, D
Pane, F
Saglio, G
Baccarani, M
Foa, R
Martinelli, G.

January 2009

The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL) with the worst c...

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).

I., Iacobucci
C. T., Storlazzi
D., Cilloni
A., Lonetti
E., Ottaviani
S., Soverini
A., Astolfi
Chiaretti, Sabina
A., Vitale
F., Messa
L., Impera
C., Baldazzi
P., D'Addabbo
C., Papayannidis
A., Lonoce
S., Colarossi
Vignetti, Marco
P. P., Piccaluga
S., Paolini
D., Russo
F., Pane
G., Saglio
M., Baccarani
Foa, Roberto
G., Martinelli

January 2009

The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL) with the worst c...

Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method.

July 2015

none24siBACKGROUND: Ikaros is the prototypic member of a Kruppel-like zinc finger transcription fact...

IKZF1 (Ikaros) Deletions in BCR-ABL1-Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report

MARTINELLI, GIOVANNI
IACOBUCCI, ILARIA
SOVERINI, SIMONA
PAPAYANNIDIS, CRISTINA
PAOLINI, STEFANIA
BACCARANI, MICHELE
Storlazzi CT
Vignetti M
Paoloni F
Cilloni D
Vitale A
Chiaretti S
Cimino G
Elia L
Fazi P
Meloni G
Amadori S
Saglio G
Pane F
Foà R.

January 2009

PURPOSE: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia...

Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia

Hashiguchi, Junichi
Onozawa, Masahiro
Oguri, Satoshi
Fujisawa, Shinichi
Tsuji, Masahisa
Okada, Kohei
Nakagawa, Masao
Hashimoto, Daigo
Kahata, Kaoru
Kondo, Takeshi
Shimizu, Chikara
Teshima, Takanori

July 2018

Intragenic deletion of IKZF1 is a recurrent genomic alteration in acute lymphoblastic leukemia. The ...

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report

Martinelli, Giovanni
I., Iacobucci
C. T., Storlazzi
Vignetti, Marco
F., Paoloni
D., Cilloni
S., Soverini
A., Vitale
Chiaretti, Sabina
Cimino, Giuseppe
C., Papayannidis
S., Paolini
L., Elia
P., Fazi
Meloni, Giovanna
S., Amadori
G., Saglio
F., Pane
M., Baccarani
Foa, Roberto

January 2009

Purpose: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia...

IKZF1 (IKAROS) DELETIONS IN BCR-ABL1 POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA ARE ASSOCIATED WITH AN IMPAIRED B-CELL DIFFERENTIATION AND POOR OUTCOME

July 2015

none25Introduction. The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukaemia (...

IKZF1 (IKAROS) DELETIONS ARE A CENTRAL EVENT IN THE PATHOGENESIS OF BCR-ABL1 POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

IACOBUCCI, ILARIA
OTTAVIANI, EMANUELA
LONETTI, ANNALISA
ASTOLFI, ANNALISA
TESTONI, NICOLETTA
BALDAZZI, CARMEN
SOVERINI, SIMONA
PAOLINI, STEFANIA
PAPAYANNIDIS, CRISTINA
MARTINELLI, GIOVANNI
Storlazzi T
Salmi F
Ferrari A
Impera L
Colarossi S
Gnani A
Piccaluga PP
Panagiota G
Cilloni D
Messa F
Pane
Vitale A
Chiaretti S
Foà R
Baccarani M

January 2008

The Philadelphia chromosome is the single most significant adverse prognostic marker in adult ALL. E...

IKZF1 (IKAROS) deletions as a prognostic marker in BCR-ABL1 positive acute lymphoblastic leukemia patients: A GIMEMA ALL WP Report

July 2017

none10Expression of BCR-ABL1 in hematopoietic stem cells can alone induce a chronic myeloid leukemia...

What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?

C. Palmi
M. G. Valsecchi
G. Longinotti
D. Silvestri
V. Carrino
V. Conter
A. Biondi
TE KRONNIE, GEERTRUDY
G. Cazzaniga
BASSO, GIUSEPPE

January 2013

New prognostic markers are needed for upfront identification of patients with acute lymphocytic leuk...

IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

July 2017

none24By genome-wide analyses of DNA copy number abnormalities in adult BCR-ABL1-positive ALL patien...

IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia

Iacobucci Ilaria
Iraci Nunzio
Messina Monica
Lonetti Annalisa
Chiaretti Sabina
Valli Emanuele
Ferrari Anna
Papayannidis Cristina
Paoloni Francesca
Vitale Antonella
Storlazzi Clelia Tiziana
Ottaviani Emanuela
Guadagnuolo Viviana
Durante Sandra
Vignetti Marco
Soverini Simona
Pane Fabrizio
Foà Robin
Baccarani Michele
Müschen Markus
Perini Giovanni
Martinelli Giovanni

July 2012

deletions by single nucleotide polymorphism (SNP) arrays; a sub-cohort of these patients (44%) was ...

SET-UP OF A MULTIPLEX PCR TO RAPIDLY DETECT IKZF1 (IKAROS) GENE BREAKPOINT DELETION IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Abstract

Extracted data

SET-UP OF A MULTIPLEX PCR TO RAPIDLY DETECT IKZF1 (IKAROS) GENE BREAKPOINT DELETION IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Abstract

Extracted data

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