Add to ORKGA process is disclosed for the prepn. of prostaglandins of the PGF2a-series of formula I [R = OCHMe2, NHEt; R1 = benzyl, 3-(trifluoromethyl)benzyloxy], in particular Latanoprost, Bimatoprost and Travoprost, which are active in the treatment of ocular hypertensive conditions and glaucoma. The invention also relates to novel intermediates involved in the synthesis of these prostaglandin-PGF2a derivs. Thus, Bimatoprost was prepd. starting from com. available Corey lactone diol
Gold(I) mediated MeyereSchuster rearrangement for the installation of the ‘lower’ side chain of pros...
Prostaglandins are an important class of biologically active compounds. The robust syntheses of diff...
The veterinary drug Alfaprostol and prostaglandin PGF<sub>2α</sub> have been synthesized in just nin...
A process is disclosed for the prepn. of prostaglandins of the PGF2a-series of formula I [R = OCHMe2...
The invention concerns a new process for the preparation of prostaglandin derivatives, in particular...
Two antiglaucoma drugs, bimatoprost and latanoprost, which are analogues of the prostaglandin, PGF<s...
Tafluprost (AFP-168, 5) is a unique 15-deoxy-15,15-difluoro-16-phenoxy prostaglandin F2α (PGF2α) ana...
An efficient and stereocontrolled synthesis of prostaglandins from cyclopentadiene monoepoxide is de...
We report a general, catalyst-controlled route to prostaglandin F2α and its analogues. The approach ...
Bimatoprost (1) and Latanoprost (2) are prostaglandin analogues widely used for glaucoma treatment. ...
Gold(I) mediated Meyer Schuster rearrangement for the installation of the 'lower' side chain of pros...
The synthesis of an important intermediate (36) in a total synthesis of the prostaglandins was under...
Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the fo...
Latanoprostene bunod is chemically known as s 4-(Nitrooxy)butyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-...
The present invention relates to new prostaglandin derivatives having improved pharmacological activ...
Gold(I) mediated MeyereSchuster rearrangement for the installation of the ‘lower’ side chain of pros...
Prostaglandins are an important class of biologically active compounds. The robust syntheses of diff...
The veterinary drug Alfaprostol and prostaglandin PGF<sub>2α</sub> have been synthesized in just nin...
A process is disclosed for the prepn. of prostaglandins of the PGF2a-series of formula I [R = OCHMe2...
The invention concerns a new process for the preparation of prostaglandin derivatives, in particular...
Two antiglaucoma drugs, bimatoprost and latanoprost, which are analogues of the prostaglandin, PGF<s...
Tafluprost (AFP-168, 5) is a unique 15-deoxy-15,15-difluoro-16-phenoxy prostaglandin F2α (PGF2α) ana...
An efficient and stereocontrolled synthesis of prostaglandins from cyclopentadiene monoepoxide is de...
We report a general, catalyst-controlled route to prostaglandin F2α and its analogues. The approach ...
Bimatoprost (1) and Latanoprost (2) are prostaglandin analogues widely used for glaucoma treatment. ...
Gold(I) mediated Meyer Schuster rearrangement for the installation of the 'lower' side chain of pros...
The synthesis of an important intermediate (36) in a total synthesis of the prostaglandins was under...
Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the fo...
Latanoprostene bunod is chemically known as s 4-(Nitrooxy)butyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-...
The present invention relates to new prostaglandin derivatives having improved pharmacological activ...
Gold(I) mediated MeyereSchuster rearrangement for the installation of the ‘lower’ side chain of pros...
Prostaglandins are an important class of biologically active compounds. The robust syntheses of diff...
The veterinary drug Alfaprostol and prostaglandin PGF<sub>2α</sub> have been synthesized in just nin...
