Central precocious puberty:short-term comparative data of treatment with monthly or long-acting thre months depot triptorelin

none12Background: Depot GnRH analogs represent the treatment of choice for central precocious puberty (CPP). Few data are available on pubertal suppression for the newer 3-month formulations. In addition, comparison between the monthly and quarterly tripotorelin depot is lacking. Aim: To assess the efficacy on pituitary and gonadal suppression of triptorelin 11.25 mg/3 months in girls with CPP and to compare the new formulation with triptorelin 3.75 mg/28 days. Patients and Methods: Thirty-five girls with clinical and endocrine diagnosis of CPP (puberty onset <8 yr). All but three girls were White Italians (Indian n = 2; Hungarian, n = 1). The girls were admitted to treatment with triptorelin depot (IPSEN-Biotech, Milan, Italy) in quarterly (group A: n = 15) or monthly (group B: n = 20) formulation. Patients were re-evaluated after 3 and 6 months of therapy. Results: In both groups, peak LH values (IU/I) were significantly decreased (p